Small molecules Cell Cycle/DNA Damage Chemical Structure : Adavosertib CAS No.: 955365-80-7 聽 Adavosertib(AZD-1775;MK-1775) Catalog No.: URK-V1391聽聽Only Used For Lab. A potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM. 聽 Biological Activity A potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM; exhibits ATP-competitive and highly selective against other serine/threonine or tyrosine kinases; inhibits phosphorylation of CDC2 at Tyr15 in cells; potentiates tumor growth inhibition in vivo. Lung Cancer Phase 2 Clinical 聽 Physicochemical Properties M.Wt500.595 FormulaC27H32N8O2 CAS No.955365-80-7 StorageSolide Powder -20 掳C 3years; 4掳C 2yearsIn Solvent -80掳C 6 Months -20掳C 1 Months Solubility10 mM in DMSO Chemical Name3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- 聽 References 1. Hirai H, et al. Mol Cancer Ther. 2009 Nov;8(11):2992-3000. 2. Hirai H, et al. Cancer Biol Ther. 2010 Apr 1;9(7):514-22. 3. Bridges KA, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-48. 聽 URK-V1199_COA URK-V1199_SDS URK-V1199_SDS 聽 Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use! 聽Small molecules Cell Cycle/DNA Damage website:http://www.ureiko-chem.com/inhibitors-agonists/cell-cycle-dna-damage/